How much pressure are you generating running at Weatherby speeds?
The joy of working with any wildcat is understanding excessive pressure, when you have no way to measure exact pressure.
It is like knowing maximum Roberts pressure limits listed in manuals is severely over exaggerated if you understand a modern action is capable of the same limits as any other cartridge!
Common sense is priceless, and if a modern action is capable of 60,000 psi with a 300 mag then so is the action safe with 60,000 psi chambered in 257 Roberts. One must also understand that is done with a safety factor, not a failure point.
Then understanding any cartridge of the same caliber needing special powders like Rutumbo to fill the case to reach such pressure needs a longer barrel to benefit the full burn benefit. Now the same pressure in a smaller case using 4831 or 7828 can give even more velocity using a shorter tube to optimize this burn.
There are so many variables to determine optimum pressure, bore, case, barrel length, and finding not only the most efficient combination, but that safe pressure becomes an art we must work with and approach slowly while looking for many different signs of reaching unsafe pressure at the same time.
But trust me, if I can use R-P 257 Roberts brass, while understanding the same brass displaying a +P designation on the head is no different than without it, and still hold primers after 3 or 4 firings, we are talking very safe pressure!
Sadly many not understanding anything I just said think that +P means it's different brass, or that 48,000 max pressure is the maximum for a 257 Roberts, and not understanding why that would be the limit, or understanding military type Mauser, Springfield, and other dated action differance from a 700 Remington, 77 Ruger, 110 Savage, etc etc, should never play where absolute pressures cannot be confirmed!
A lifetime of loading cartridges without pressure data is something you simply can't teach or explain in a post, and most know when we are talking cartridges such as 257AI, 25/284, 25x47L, 25x35, all in custom chambers, are territory most work without a means of verifying absolute pressures. But most who enjoy working with such combinations are extremely experienced working with and understanding a multitude of variables pertaining to the combination being brought to be.
Those that have to ask an absolute, should probably refrain from playing with such combinations, without supervision, or until more experiance is obtained.
This is just the way it is.