Personally I think there I a big misconception in using a Weatherby, or 25/06 AI! First off 3000 to 3100 is all the faster you can run a bullet out of a 1-8 to 1-7 twist barrel before the accuracy starts opening back up. TO MANY RPM'S!
I will always stand behind my belief that the 257 Roberts AI is the most efficient cartrige ever chambered for the 1/4 bore! Along with a 1-10 twist being the sweet spot for speed, accuracy, and hunting weight bullets!
85 grain to 117 grain gives you as good as any for both varmint, and game up to mule deer out to 600 yards. Plus the best accuracy you can get from any bullet beyond 3200 fps. And from a 26 to 27 inch barrel, 3200 fps is atainable.
A 135 grain won't shoot any more accurate at 3200 from the bigger cases, but will be less desirable than a Hornady Interlock, Nosler Partition, or ant bullet intended to give the terminal performance on game.
The big thing is on varmints @ 3550 fps with 85 grain BT's it is devastating out past 600 yards, just don't expect it to pelt friendly.
And as far as brass goes, anything those thinking is so great for the 25/06 AI, which is no faster, with 20% more powder to accomplish the same thing, and suffer even greater throat erosion to do that, why not use those cases that are supposedly better in the 257AI?
I been there with 25/06, Roberts, and Weatherby, the BOB AI is the only 1/4 bore I would consider if I wanted one at its best. With a 1-10 twist, and nothing heavier than 117's,,, unless my target was made of paper! For anything bigger, that's when I would step to a 30 cal.
As far as I'm concerned, bige game starts at Antelope, and hunting them up to Mule Deer my caliber would start at 25. For Elk and bigger, 30 cal or 35 cal. But would never grab a 6.5, it won't do what the 25 will with varmint bullets, and no better for antilope and big deer, and I would never consider it over 30 cal for Elk or bigger!