Been at it seriously since 1968, and agree that the 22-250 is most excellent for coyotes, LR rockchucks and the like, but it's a barrel burner in a hot sage rat patch. Seen at least three of them totally destroyed in just over two days shooting ground squirrels here when we were loaded with copious amounts of rats.
The "old" 223 is about the best sage rat caliber if a guy was to own just one rifle.
The .22-250 Rem case CAN easily Be, "Down Loaded" to .223 Velocities or, LESS with, H-4895, IMR 4895, Varget, powders,. etc. and it's, STILL,.. Very Accurate ( Great Tapered, Case Design, Just use, Caution, on Shoulder BUMP ! ).
The Only,.. Small to Large Varmint Cartridge that, anyone, really Needs,.. IF,.. a Handloader.
50-52 grain, Bullets at, 3,400- 3,500 FPS with, NO,.. Muzzle "Jump" and SUB 1/2 MOA, "Works" for,.. Me !
One MUST Learn to, PACE themselves, on a HOT Day of, PD or Sage Rat shooting, tho ! Cool Head= COOL Barrel !
I'll NEVER be without, a .22-250 Rem or Ai as, they ARE so,.. "Variable",.. in USE !
From, Sage Rats/ PD's ( w/ 40gr- 52 gr. ) to, Yotes ( w/ 55's - 60's at, 3,500 ) and even, Deer with, the RIGHT Bullet