Sierra 1365 is a Sierra Game King, 55 grain, good bullet.I’ve shot many dozens with Sierra 1365’s and H4895 out of 22-250’s on deer damage permit. I also have had very good luck with hornady 55&60sp
Agree with this. 60 gr Partitions have had very spotty availability. The Nosler 64 BSB is an excellent bullet and will hold up well to 22-250 velocities without issue and provide pass throughs. While not a cheap bullet, they are not nearly as expensive as a Partition or Barnes. It has worked great for me on several hogs out of a 223 running around 2850 fps. It also will generally stabilize in fairly slow twist barrels.Nosler’s 64gr BSB is an excellent deer bullet. I load them in my daughter’s 22-250 with BL-C2. Not the fastest load but it will flatten deer. Depending on brass capacity you should top out at 34-36grs.
Before going through the trouble of selecting a load, check with your state’s fish and game department to see if there is a minimum caliber for hunting deer. For example, in Virginia it must be greater than .23 caliber.A freind has a Browning lever action 22-250 he bought used. Came with primers, fired cases and a can of BL-C (2) powder. Wants to reload and hunt deer but needs a good bullet for the powder he has. He has some 55gr FMJs but the seller said not to use them because of high pressure (?) plus I told him it wasn't a good hunting bullet anyway.