I’m hesitant at all to disagree with Ned, so let’s call this another view instead.
I'm not so sure that the second sentence above (if you have to seat long...) is always correct. Often correct, perhaps even usually. The case capacity penalty might or might not be consequential to you. It depends on your case fill and such. And it also depends on where the accuracy nodes of the next lighter and next heavier bullets are with your particular powder. I'd suggest you test for yourself. I found accuracy with an 80 ELD at only 2.432" in my rifle. And I'm able to push it lower mid 2700s in an 18" AR. Warm load, yes. But it went 193 at 500y. Now, I know that's nothing special to most F-classers, but this was an 18" AR off a light folding bipod with a squeeze bag and a 15x scope in some pretty awful conditions, such that a 193 was the 3rd highest score at 500y in all of F-class. This is not a match rifle, it is a heavy barrel 18" AR with a NATO chamber. I'd expect normally it wouldn't be competitive even in FTR, never mind F-open.
This is why I don't think at all that it's a given that you have to have a rifle throated to the moon to run a heavy bullet effectively. It really depends on the OAL and powder charge wt where you find accuracy in your gun.
Varget and H4895 are super popular powders for a reason--they work well. I've personally had great luck with 8208xbr also and AR Comp too, so don't shy away from them if you have some on hand.