I was playing with 300 Whisper and 230 Bergers out of a bolt gun a couple years ago. Bartlien 7 twist in a Bighorn/Zermatt TL-3.
Vhit N-110 gave the best ES/SD of any of the powders I tried initially. Once I found a promising load I stared playing with seating depth.
At 100 yards a so-so 3/4 inch group went below a 1/2 inch group with a little seating depth playing.
I sold the rifle and ended up with a DTA bullpup with a Brux barrel and repeated it. Same reamer. Same end result.
With the 300 it worked for me.
Next project is my 510 Whisper. I just need the time and energy to work up a load. Ironically, Vhit N-110 also showed the most promise so far.