Save yourself the effort and simply do a little math to reach the [correct] conclusion that the effect of a single kernel charge weight variance cannot reliably be registered by most (if not all) chronographs commonly employed by shooters. If the chronograph cannot reliably measure the difference in velocity, by analogy, that difference is effectively meaningless because the whole point of weighing charges precisely is to minimize velocity variance.
As an example below, the average kernel of Varget weighs approximately 0.022 gr. In a small cartridge such as the .223 Rem, the effect of a given charge weight variance would greater than in a much larger cartridge with increased case capacity. For that reason, different values would obviously be obtained with powders having different kernel weights or cartridges of different capacity. However, they won't generally be hugely different. Using actual average velocity values from one of my .223 Rem loads with Varget and 90 VLDs, here is an illustration: 24.3 gr Varget yielded an average velocity of 2763 fps (ES - 17 fps, SD - 8.5 fps).
2763 fps/24.3 gr = 113.7 fps per grain; or ~11.4 fps per 0.1 gr
There are ~4.6 kernels of Varget per 0.1 gr, so:
(11.4 fps/0.1 gr) X (0.1 gr/4.6 kernels) =
~2.5 fps predicted velocity change per kernel Varget
First, it would be a stretch to think that most chronographs are accurate in the 1 to 2 fps range. If any are, it would be at the extreme limit of their accuracy/precision. Further, the 2.5 fps per kernel Varget theoretical velocity
estimate is well below even the best ES values that shooters would routinely obtain with loads having excellent ES values, which I would classify as being somewhere in the ~4 to 7 fps range. Such low ES values are not easy to routinely obtain, even for those already weighing powder to +/- half a kernel, suggesting that the velocity variance (ES) at this level is almost certainly due to other factor(s) besides charge weight variance.
Nonetheless, sources of error can be cumulative, and weighing powder to +/- one kernel (or slightly less) is not really very difficult, so there are many that do weigh powder to that level of precision as a means to effectively remove charge weight variance as a limiting source of error. Having said that, I wouldn't really recommend anyone go out and start testing charge weights that differ by a single kernel in weight just to demonstrate a principle that can be effectively estimated far more easily. Even if someone is really masochistic enough to do this experiment, it is worth noting that having a properly calibrated analytical balance of sufficient precision (i.e. 0.0001g readability, ~0.0002g precision) would be essential before undertaking such an exercise. Don't try it using a Chargemaster.