My reasoning for not having the tuner on with a new barrel showed up in spades recently. My new 30BR Bartlein 1:17 shot great the first time out. On subsequent sessions to try another bullet, it got a bit fussy about vertical. On the third range session, it became virtually untuneable with multiple powders, three different bullets (two Nyhus'...whoever that dirt clod may be...and a BIB), seating depth changes, ad nauseum. I knocked the gun apart and went over everything. No joy. It would shoot small for one group and the next group would be a mid .2 with a couple of Mickey Mouse ears.
Today, with a new scope on the gun it shoots like a real BR gun again with my .3084/.3086.117's. Good thing too as Grandpa's straight edge razor was starting to look pretty good.
It's easy to get lost when you're trying to deal with sneaky stuff like this. I can't fathom working through something like this by having a tuner in the mix right from the get go.