If you practice, gain the skills, have good equipment and are capable of declining a marginal shot, their is no reason not to take advantage of the potential of modern rifles. It's definetly not for everyone, and that is as it should be.
Jim
X2
New myself (here) so my 2 cents isnt worth much to many but, that said, Jim hit this on the nose.
Regardless of choice of round, gun...or any OTHER choice of hunting weapon, there is a combination of the shooter's limitations coupled with the capabilities of their choice in equipment that not only needs to be strictly adhered to but JUST as important, that limitation must be FOUND.
Most here have said so as much talking about PRACTICING and feel the post editor realizes this.
I WOULDNT take such shots with some of the rounds suggested but that is dictated by MY limitations only.
With the superior bullets , powders and the accuracy most really GOOD guns are capable of today, it's not NORMALLY the weapon that is the limiting factor.
One only has to go out here in IN and see uh "hunters" making or attempting to make slug guns into 300 yard deer guns to quickly realize that some flat aren't paying attention NOR do they go out before season and find out what their limitations ARE.
Some here can wax a deer at 600 yards,with a good rest, and a gun and caliber they are VERY familiar with. One only has to do a bit of searching online to see others doing so WAY past 600 yards. Unfortunalely the "average" deer hunter seems to think those tasks are easy and anyone can do it.
IMHO, not many REALLY have or will take the time needed nor have the funds to invest in REALLY long range hunting guns, but yes it "can be done".
Regardless of the range, or game you seek, your own limitations need to be tested and tested and IMPROVED with practice, experience judging range, and knowing what YOUR round and bullet WILL DO.........when you do your part.
God Bless.