I shot a doe in the neck with an Anschutz 22 Hornet. She collapsed in place. Her head was turned looking in my direction. The bullet hit the curve of her spine, ran down along it, and ended up just above her brisket.A few years ago Minnesota legalized any center-fire .224 cartridge for deer. One fall I used my Winchester model 43 in 22Hornet, 35 grain pill with a max charge of H-110. I hunted a few days waiting for a clear standing shot. About the third day a nice young buck stuck his head out of the brush. I hit it 2" below the ear, it was dead before it hit the ground.