With your setup, I think you should be able to hit Node 4 (~1.090 ms for a 23.75" barrel). However, I would suggest using Hodgdon 322 instead of Varget for a couple reasons. First, H322 has very small kernels compared to Varget, which are easier to measure precisely and consistently for a small case like the .223 Rem. Second, Varget is going to be fairly slow in your setup, especially with the relatively short barrel. A slightly faster powder like H322 will help get that 80.5 gr bullet moving in the shorter pipe.
Some time ago, I worked up a load for a .223 Rem F-TR bolt rifle with a 26" barrel. It was one of the first loads I ever worked up, so I did it without the aid of QL, using ladder and OCW testing. This load was a bit unique, because that particular rifle has "zero" freebore. Because of that and the relatively short barrel, I went with H322. I only found out much later that the optimized load I came up with was, in fact, on OBT Node 4. I ended up using 22.5 gr H322, Lapua brass, Fed 205 primer. I found out the hard way that when the bearing surface/ogive transition is slightly below the neck, if you don't use a comparator insert with a smaller hole like Hornady's, you're effectively just measuring case length for a loaded rounds. In any event, I got everything worked out and have shot this load for several years in MR F-TR matches with very good results, particularly at 300 yd.
With the 26" barrel, I am getting about 2860 fps. Predicted pressure is running in the 56-57K psi range, but I have not had any issues with brass life as yet. However, I worked up about 400 pieces for this rifle and am only on the ~5th firing at this point. I have been very pleased with the performance of the H322 in this application. You have quite a bit more freebore than I do (zero versus an estimated .075" based on your COAL measurement above) and can seat the 80.5s longer, which should lower your relative pressure a bit.
QL parameters: barrel = 26.0", brass length = 1.750", bullet OAL = 1.082", case volume = 30.59 gr, temp = 70 degrees F, COAL = 2.330" (CBTO = 1.851", ~ .018" off the lands). Output below: