I usually start thinking about a project about 2 projects early,,got a PPC bbl at smith now and want to rebbl my first deer rifle next that was an A prefix 700 BDL 25-06 that has melted 3 bbls,,probably gonna do it in a 280AI to shoot the 168 VLDH,,then I want a 22 that will shoot the 75VLD -80 AMax class bullets to shoot at 400 500 yards
anybody shoot a
22BR
22 Dasher
fast twist 22-250 or maybe even a 8 twist 220 Swift
a 22XC might be a killer caliber also to crank out the 80 Amax or SMKs at speeds that would be lazer flat wind beaters,,
anybody know what the best way to get the 75-80 gr bullets in the 3250-3300 fps range with good case life and top accuracy
		
		
	 
Mr. Big -
Howdy !
Your stated velocity range for  .224" cal  75 - 80gr bullets is certainly  do-able.
I can tell you that my wildcat   .22-35 Remington w/  28"  K & P  SS  1-8  would give 3,420fps from my accuracy/field load of:
40.5gr  AA3100  and FED LR Match primer  under  75gr "A"-Max.    Primer switch to FED LR Magnum Rifle Match primer upped vel to 3,500fps, with slight opening of groups.   After rifle  assembly,  I found that I could have  gone   w/ a  29" barrel, and still fit in a Plano  " Airglide ".
I use 450 ft lb as the minimum threshold value, for enhanced lethality on groundhogs  @ distance.   In  a  29" barrel,  .22-35  shooting 75 "A"-Max
would be capable of 450 ft lb @ 1,000yd, using an appropriate powder choice.   The "A"-Max was good for both target work and on groundhogs.   
If I were to step-off on a new  .224" cal wildcat right now,  I'd probably have the chamber cut by running  a  " .22-6mm Rem "  reamer in short; for a nominal  .466" base diam.     The .224" cal wildcat would be case formed  by running  7 X 64 Brenneke brass up-into a   6.5 X 55 Swedish  FL die 
( LEE ).    I say that because  I  formed my  " DEEP 6 "  wildcat brass using  7 X 64 as the parent case, doing the shoulder shove and neck-down in the  6.5 X 55 die  ( w/ its internal removed, to make the die open-topped ).   When forming  " DEEP 6 " brass, the wildcat cases emerge from the forming die   initially...... as .22" calibre.   I inside neck ream  & outside neck turn, to arrive @ final 6mm cal and neck wall thickness I  need.
This fore-shortened version  of  the  " .22-6mm "  would have case capacity  >  .220 Swift; which holds  48gr H2O.   My estimate would be 50+ gr,
as  DEEP 6  holds  51.2gr H2O; and  smaller neck diam  of the .224" cal variant would reduce case capacity a bit from  that  amount. 
It'd be interesting to see what this wildcat could do,  w/  a temp-insensitive  powder.... like IMR 4955.
Other thoughts:
If you don't think you'd be likely to shoot much past 600yd very often, a slower twist barrel set-up for  65 -69gr  .224" cal bullets might hold appeal.
Sierra's  .224" cal  65gr SPBT has close to the same BC as the well established  68-69br HPBTs.   For a less temp sensitive powder choice,
IMR4451  could be  one  way to go.
With regards,
                    357Mag