I use a 300 zero on both of my coyote rifles... 20-250 AI... and 22-243 AI... they both drop 7 inches at 400 yds, so I don't even move the turrets until past that range... just hold a tad high in the body, and let it drop in... works Great... Easy Pezzy
I use the 7 inch body width for a killing zone... or better yet... 6 inches... the size of a dollar bill.
My highest bullet arch is almost 3 in.. (2 3/4).. at 150 yds... which is easy to allow for on close shots... I still just point and shoot. You can stay on fur out to 400 yds, and kill'em dead.
Im shooting a 22/243 with the exact zero, set up. As said if close hold a little low or hold high if father off. when i haven had time to range on a few long shots ive held with just a sliver of light between the back and cross hairs and let drop in. Calibers like these may not be for every one but they sure make hunting fun when a coyote stands broad side thinking they are safe so far off and you can still bust their ass so easy.