Interesting conversation.
As someone who went from F-class to PRS, I gained some insight that many have not taken into account.
First, the smaller the rifle shoots, the bigger the target becomes. What does that mean? It means that if you are shooting a 1 MOA rifle at a 1 MOA target, to hit it reliably, you better be centered - precisely. If you upgrade to a 1/2 MOA rifle, you now have about 1/4 MOA each side of center that will result in a hit. With a 1/4 MOA rifle, you would have 3/8 MOA to play with.
Since centering includes the wind call, gaining any "give" is a benefit that will pay out in more points over time. It is oddly identical to F-class that way.
Second is the constraints of the game. In Benchrest, you get to clean your barrel, make load tweaks, and/or shoot sighters to define/refine your tune. In F-Class you also have the opportunity to shoot sighters if you want to twist the knob a bit and roll the dice, you are able to. In PRS, you are constrained more. You take all of your ammo and your rifle out for the day. If it shoots in the morning, but not the afternoon, you get to suffer the consequences because every shot is scored. The more mature way to look at it is that a stable load is required. In other words, you need something that will perform well throughout wind, rain, heat, and cold. There is also a conversation on tuning diminishing returns to be had for both F-class and PRS (but not here).
I certainly don't shoot PRS at a high level yet, but this is only my second year, and I am progressing. My greater-than spring chicken age is not helping...