I would think that a 7mm of some sort would be the ticket here. 100 gr bullets for the varmints and 140-160 gr for the bigger stuff. 7mm-08? Obviously both are somewhat of a compromise. My 2 gun hunting battery is a 6.5x47 (whitetail and coyotes) and a 280AI for whitetail + mule deer and elk in future. In process of getting another 280AI built. 6.5x47 will be my only whitetail gun this year.