I wasn't lucky enough to own a rifle that could cluster them into anything better than 1.5 MOA...sometimes worse. Good enough for hunting I guess.
This is about what I have experienced with them. They are a definite killer, so forget about good groups and just go kill an animal. I couldn't even get 2" groups with the 60 grain 224 partitions...they fly all over the place. I even tried them in a 1-in-9 barrel. If you want a bullet that reliably kills and will still shoot a nice group try the Long range Accu-Bond.
Basically, the answer to the op is NOUse them with 243 100gr and 280 Remington with 160 on deer with no problems at all.
Good to know bud. I'll be using my 22-250 AI with some partitions to fill a doe tag this fall. I'll give you my results after Nov.You will need a 12 twist to get great accuracy with the .224 partition with the 14 twist shooting 1 1/2-2 1/2" groups.
In a 22/250, the 60g Partition will do more damage to a deer than a 30/06 with a 150g Sp.