I grew up in prairie dog country and over the years I have tryed to find the perfict rifle for shooting them. I have used Anschutz, Browning, Cooper, Kimber, Howa, Remington , Ruger , Sako,and Winchester,, all were bolt action rifles. They were a mix of sporter and varmint rifles. I started reloading ammo in 1953 so all I use is reloaded ammo in them. My goal was to get the center fire rifles to shoot 1/2 inch five shot 100 yard groups off a bench rest. Some of the actions were glass bedded, barrel free floated, triggers adjusted to a 2 3/4- 3 Lb pull. A few needed the bolt locking luggs lapped,and the muzzle recrowned. I have a mix of scope brands but most are Leupold and Burris. I like 6-18X AO and have a few 6.5-20 X AO scopes and lesser power on the rimfire rifles. So far the cartridges used were 17 HM2, 17 HMR, 17 Fireball, 17 Rem, 204 Ruger, 22 LR RF, 22 WMR, 22 Hornet, 221 Fireball, 222 Rem, 223 Rem, 22-250 Rem, 220 Swift, and 243 Win. For spring shooting when there a lot of p dog pups shots within 150 yards the 17 rimfires are used with the 17 Fireball rifle. By mid summer Ill use the 204 Ruger rifle , Prairie dogs get muzzle blast smart so I limit tje use of the 22-250 Rem, 220 Swift and 243 for longer rang shooting. --- If I could have only one rifle it would be one that fired the 204 Ruger round , It would be varmint weight with a 6-18 X AO leupold scope. My second rifle would be a 17 HMR. But come next spring I ll be trying out a 17 Hornady Hornet, Its Low muzzle blast and recoil , flat shooting out to about 250 yards could make it a fine prairie dog pup shooter.