Unlike a .20 cal AR-15, a 6x45 can become somewhat constrained by standard 2.260" magazine length. Given that, stick with a 1:10 twist and run </= 75grain bullets, as going heavier (longer) results in too much case capacity occupied by a deeply seated bullet. I have a 6x45AI bolt gun on a 1:8, Simply because a bolt gun setup allows ~.250" more magazine capacity than an AR allows. That makes a huge difference in performance potential! The ability to seat a heavy bullet out long lets ya run a full case of powder behind it. That just can't happen in a magazine fed AR, as limited OAL stifles capacity when a long bullet has to get stuffed down the neck in order to clear/cycle in semi-auto 100%...
When shot side by side with a 6x45, the flatter trajectory of a .20cailber is quite evident. Of course, you're paying for that performance with decreased barrel life.
You can bang away with a 6x45, where a .20cal will heat up, fast. Both kill varmints well...
If you have any inkling of big game huntin with your AR, the 6x45 is a no brainer.
A 6x45 will be more efficient from a 'short' barrel...an 18-20" is dandy! Yet, going less than 22" on a .20cal is really cuttin' into performance potential.
If you do want a .20 caliber AR, just build a .20Practical. At the time I had mine built, Dakota was producing .20TAC brass, so that's what I went with. Today, I'd do a .20Prac & enjoy the brass bonanza.
The .204 Ruger is a fine cartridge, but it's extra case length doesn't make it ideal for cycling in an AR. That's not to say a .204R won't feed, just that a .20Prac retains parent case shape that that AR was designed to function on. And being that ARs like to beat up brass, you can run any matter of cheap, available brass and not give it a second thought...
Oh yeah, 1:10 for the .20 Practical, too! 32-40gr bullets with no worries...
Have fun!