I am set up to load at the range. I run a pressure test,starting at a load that is safe, but below the velocity that I am looking for, shoot one shot per load, in increments that vary with the case size, usually about .3 gr. in a varmint cartridge, all at the same target, on a day with good conditions, using wind flags. When get to the point that I am experiencing slight bolt stickiness with FL sized cases, I note the temp. and humidity, and look at the target, and my notes to see where there may be a cluster of shots, and in what range of powder charges this has occurred. I then load up three with a charge in the middle of this range, and retest. I do all of the above with a seating depth that experience tells me will work, almost always longer than touch. After I have a powder charge that seems to be working, I play with seating depth by small amounts. Another thing, I usually do the initial pressure series over a chronograph. This method seems to work, giving the best results in the shortest time, and with the fewest shots, wasted components, and barrel wear.