Several years back I went exclusively to the 223 Rem bolt rifles for all my varmint and predator hunting. This proved to be a very successful move for me.
Of course, here in the east, we don't have nearly the shot opportunities that "pdog" hunters have so barrel heat is not an issue. Also, where I hunt, safe shot opportunities rarely exceed 300 yards, well within the capabilities of the 223 Rem. The reduce noise, economy, and performance of the 223 Rem works very well for me. While I am not obsessed with barrel life which I consider a consumable, I have spent a lot of time at the range (2 to 3 days a week) practicing off my cross sticks. Therefore, the mild effect of the 223 on barrel wear and low recoil is welcomed.
For me, the Nosler 50 and 55 gain BT's give me the best precision in my 12" twist 223 Rems. For my 8" twist rifles (Tikkas), the 60 Vmax gives me the best performance especially for predators.
For of course, wind is the challenge for a varmint hunter due to the small vital area. I never really mastered it, but I've managed to achieve modest success dealing with it by taking crawler shots in the wind and trying to time the shot between gusts.
While I am at the end of my hunting avocation, I've learned a lot over the years. That's the supreme irony, I've come to the point where over the 50+years of hunting I have worked out all the details, i.e. equipment, loads, techniques, and skills but my body has worn out. Such is life. Yet I am grateful because I had a tremendous run with many great hunts.
Enjoy your hunt - cherish the time spent in the field. In my humble opinion, hunting under field conditions is the ultimate test of a rifleman, combat notwithstanding. Best wishes.