As with many things, there are a range of different reloading approaches that will usually get you to about the same endpoint. Optimization of charge weight followed by seating depth is a pretty standard approach that can work very well.
The rifle will tell you at what velocity it gives the best precision, not the other way around. Further, this can only be determined by actual testing. However, with any given bullet, I usually have a very good idea of the velocity window where it will likely tune in well before I ever load them up. It's usually not too difficult to find out here the velocities people are running a certain bullet from a certain barrel length. I also use use an approach known as Optimal Barrel Time (OBT), which focuses on barrel occupancy times, rather than velocities, per se. The theory behind this approach has been hotly debated for some time, so you'll find a love/hate relationship with many shooters regarding OBT. It works for me and allows me to make good use of the reloading program QuickLoad (Neco), so I don't particularly care whether the proposed mechanism is correct or not. If you're interested, here is a link to OBT:
http://the-long-family.com/optimal barrel time.htm. In any event, whether from reading at online shooting forums or using computer predictions and optimal barrel times, I generally have a fairly good idea where the load velocity will end up before even starting. The main thing is to test a wide enough range to see both boundaries of any optimal window, so you can define the center of the window and load to it.
Even if you have no idea whatsoever of what velocity to expect from a given bullet/powder/barrel length combination, you can start with the charge weight test ranges given in typical reloading manuals. Depending on whether you're loading to mag length (I don't; I single feed only, so the rounds are much longer than mag length), they will give you a place to start that will generally be conservative. You always start low and work up in reasonably small increments, not only for the obvious safety reasons, but also because if the test increments are too large, you may mis something. Sometimes people will start with a coarse increment charge weight test to cover a wider charge weight range with a smaller number of rounds and point them to some specific region within the overall range. Afterwards, they will carry out a small increment charge weight test within that specific region. You can carry out these approaches using a ladder test, Optimal Charge Weight test, or some other method, but as I mentioned before, I'm more concerned with the velocity data the first time through than the grouping, which will be tuned in later using seating depth.
Your dies are fine; I also use Redding Type-S Match dies sets. I always remove the expander ball from mine before use, YMMV. If you don't own them already, having something like the Hornady OAL gauge, a good set of calipers, and the appropriate caliper tool inserts to measure to bullet ogive and case shoulder are very useful. Once you have assembled the necessary tools and components, it's simply a case of choosing the test approach you want to use, loading up a test series, and getting started. I'm sure you will learn a lot more as you are actually doing all the steps. I personally pay very, very close attention to maintaining the highest level of consistency for three major factors: charge weight, seating depth, and neck tension. I think that if you can keep those factors uniform, the odds of developing very good handloads increases exponentially. Good luck with the process, and post your questions/progress here at Accurate Shooter; it's a very good place for information.