Never understood the heavy bullet philosophy that now dominates the varmint hunting rifle world these days. The trajectory is like a rainbow. I guess you can dial up to compensate but that usually requires an expensive scope with high quality repeatable turrets. But the more significant issue is the terminal performance of these heavy bullets on a varmint. Also, is there a tendency to ricochet because they don't expand? But as I said in the past, there are a lot of things I don't understand about today's world.
I hunted with the 22 250 for years. Mine was a Remington 700 Varmint Model, 14" twist. With 50 grain Nosler BT's and Varget / IMR 4064, this rifle was a 1/2 moa rifle capable of making shots beyond my capability (300 yards) off a shooting cross stick. It's a great long-range option but was really more than I needed in the areas I hunted. When I eventually burned out the barrel, I never replaced it. However, if I was to replace it, I would go with a 14 or 12" twist for varmint hunting to accommodate the 50 and 55 grain Nosler BT's and not over spin them.
For the past several years I have use 223 Rem's exclusively for my varmint and predator hunting and have been completely satisfied with the performance results. The long barrel life, accuracy and economy for component reloading is a significant factor in my satisfaction.
The 223 seems also plagued with the heavy bullet craze. Fortunately, I have several 12" twist rifles. For my 8" twist Tikka's, I discovered the 60 Vmax which shoots very well, and the trajectory isn't too awful bad. The terminal performance of which I haven't tested on varmints yet, but it is a real hammer on predators.
I can understand the "heavy bullet" philosophy for target shooting but I am at a lost when it comes to varmint hunting which requires a bullet with a light jacket for rapid expansion for optimum terminal performance.