Can never go wrong with listening to a man of the cloth....Preacher said:The 250 will do anything the 6.5 will do on any given day.....
A little more boiler room in the 250 over the 6.5....
I have both and would be hard pressed to choose one over the other..
A 100 grain Ballistic tip in the 250 (mines a Ackley) will flat out shoot, and deer don't like it....