You can load bolt guns up a lot more. SAAMI MAP is 52,000 psi in deference to the AR-15 bolt. European CIP Is 4,050 bar / 58, 740 psi measured in a slightly different way. The latter is what a bolt gun should happily take.
I have a Howa Mini 1500 'Oryx' chambered for the cartridge with the factory 20-inch 'heavy' (not really!) barrel. It shoots well with bullets it likes and the Howa is much better suited to single-loading rounds than the Cz527, so a bit longer than standards COALs can be employed where the chamber throat allows. With 20 inches up front, c. 2,400 fps is feasible coupled to half-MOA five shot groups from 120s and 123s.
Case capacity is the limiting factor in both MVs and bullet weights. 2,400 is quite achievable with small grain extrudeds - my favourite is Viht N133, but have yet to try Alliant AR-Comp which has a good reputation. For higher MVs, the higher-energy/denser ball powders such as Ramshot TAC, Accurate-2520, Lovex DO73.6 (Shooter World 'Match Rifle' in the US), and probably best of all Hodgdon CFE-223 are needed. With the MTR's longer barrel, you should get above 2,500 fps with 123s with them. Although some companies give loads for 140gn class bullets, I believe 130gn is the practical / ballistic limit. (I hope great things from the 130gn Berger OTM Tactical in the Howa.)
Sadly thanks to Covid and six months aggregate lockdowns since a year ago closing the ranges and banning travel in the UK, my ability to do further development / testing on the little Grendel has been heavily curtailed.
Run the external ballistics for the best of the 123s (new version 'pointed' 123gn SMK according to Bryan Litz, maybe the Nosler RDF which his bullet review book doesn't include) at around 2,500 fps and you're transonic around 900 yards and passing through the sound barrier before 1,100 in standard ballistic conditions. (But being in Oz, you may shoot under far more favourable ambient conditions.) Modern HPBT match bullets often perform very well too even when going trans and subsonic - but you don't know until you try. Nevertheless, I'd have thought the Grendel marginal for 1,200 yards plates. But if you shoot at 4,000 ft ASL in temperatures in the 90s, you'd likely be fine.
For everything to do with the cartridge, components, loads and its rifles, there is a specialised owners' forum
65grendel.com