In an attempt to be more direct with a reply, here is the general direction that I ran this cartridge when the .300 WSM was released. We necked the .300 WSM case up and down just like every other builder did trying to be first with the results of all the other calibers on that case...

So...
The limit here is the Winchester magazine box. You will be constrained by the box length as opposed to using a DBM or Wyatt's. Working with that 2.8" to 2.825" length, adding the longer heavier bullets just eats up case capacity like they did with the venerable .350 Rem Mag. years ago although it's not as significant as others might suggest.
This is not a target rifle so pick the range at which you feel comfortable shooting at game and work from there. Be sure to include the danger factor in case you decide on something like maybe BEAR?
I tested some of the pointy bullets with fair success although this cartridge seemed to perform well with the slightly more blunt bullets like the 225 Nosler Partition and especially the 225 Woodleigh PP or the SN. Several Missouri deer fell to this combination over 2 seasons.
Powders which were successful with the above bullets included your Re-15 and IMR-3031 or VVN-540. You will have plenty of power for 300 - 500 yards and the most general shooting from close in to 250 yards if you hunt the wooded ranges. Normal performance fell into the 2,800 fps. slot for the above bullets and nearly 4,000 ft/lbs of energy.
Enjoy!