I also have a 22-250 in a vssf-ll , it likes 37.5 grains of h-380 with 55g nosler bt seated 0.024 off the lands with cci primers a 5 shot group at 100yds was around 3/8'' consistantly,I tried varget with the noslers and the v-max and it didn't shoot to my liking,It is a great gun and fun to shoot