I have both versions of the .22-250, and the difference between their ballistic performance is negligible. My latest rifle is a Remington 700 built on a new blueprinted action, with a 24" Pac-Nor 1:9" twist barrel in .22-250 Ackley, equipped with the Pac-Nor Remington Savage style barrel nut. I also bought a .22-250 Remington varmint contour Bergara 1:12" twist barrel, which also uses a barrel nut. Both barrels installed on this action shoot sub .5" groups @ 100 yards with the Ackley developing best accuracy at around 3,600 - 3,700 fps, while the standard .22-250 Remington develops its best accuracy in the exact same velocity range, within a few feet per second. This is true with my other .22-250 Remington rifles including a 1:10" twist 40X. I use primarily Barnes 50 grain Varmint Grenades (lead free zone) and the Nosler 52 grain Custom Competition bullet, hence the need for a faster twist with the Varmint Grenade. All the .224" bores of all twists also shoot superbly with Nosler's 40 grain BT Lead Free bullet.
Please note that I didn't say higher velocities were not obtainable, but that my experience is that best accuracy usually falls somewhere around 3,700 fps.
I use a Hornady Custom Hydraulic Case Forming Die, and Full Length die set, both matched to my chamber by Hornady's Custom Shop to produce the .22-250 Ackley brass without fire forming. I have come to the conclusion that there is no real advantage, other than scratching the tinker's itch, to bother with the Ackley version. On ground squirrels both are equally devastating at the same ranges, but the smaller and more economical .204 Ruger and .223 Remington both offer similar air time and splat factor.
If you want a .22-250 Ackley barrel for a Savage action, I suggest a purpose built custom barrel, either a Brux from Sharp Shooter Supply, or a Pac-Nor or Shilen prefit, all top quality products. My Savage barrels all come from these sources, but be prepared to spend $500 - $600 dollars.