One thing that very few folks think of is that whether or not you use use the hold over method or have your scope marked for different yardages, is that the wind conditions, wind angle, altitude, and %humidity does change your zero. When you are dealing with a 15 or more MPH wind quartering at you, your zero has is not worth spit. When you are shooting with a direct head wind, your zero had changed a LOT! If you are shooting a 15 MPH cross wind at 300 yards, your preset zero is useless!
I learned a lot from a National Champion Over the Course shooter Mid Tompkins shooting an M1-A. He explained to me how he dialed his knobs for the elevation, and windage for the predominant wind condition for that day. I watched him shoot off hand out to 550 yards with amazing accuracy. We met at the range often, and we would tell me how he read the wind and climate for that day, adding a click or two for this or that...changed my mind set to know that you had to be aware of wind direction and speed along with atmospheric conditions for that day. Was the air heavy like it was going to rain, or was it a bright and clear day with the air thinner.
I think that the proper mind set is to think in terms of a floating zero for the range you are shooting and the wind,angle and speed) that you are shooting.
Let me give you an example. I took a guy that was later to become my hunting partner on a dog trip to SD. I had access to a p. dog town that was 11 miles long and 3 miles wide and rarely if ever got shot because the owner was a real SOB to white folks.
I had 6 guns in the truck and my partner had 12. I had Leupold 6-20 with target knobs on everything, zero'd at 200 and clicked up from there. My partner had all kinds of various makes and powers of scopes sighted in for 200 and held over 300-450...we never had to shoot past 450. It seemed that every shot I made was a loud plop, I was constantly cranking on elevation and windage. If I hit a dog low, I would crank in two more clicks. If I were hitting them in the back legs on a broad side shot when aiming for the shoulder, then I would dial in 4 more clicks left or right, then aim for a head shot. You would wipe out all of them in a certain area and you could hold over/under just a little for shots 35 yards out or in.
My hunting partner got so mad! A 10 MPH wind in SD is a calm wind to say the least! Constantly changing directions, one side of the truck to the other got him so frustrated. He finally asked me to explain what I was doing with the knobs. After a short explanation, I loaned him a 22/250 with 6-20 leu with knobs. He hit almost ever shot out to 300 on the first shot, he did have a muzzle break on the gun so he could tell if he was also hitting the animal low or high/ left or right and adjust knobs for dogs further out accordingly. Well, he shot up all the ammo for that rifle, and I told him he would have to go back to his rifles.
He got so mad when he went back to shooting his rifles, he threw a 40x 22/250 over the side of the truck screaming how "no good" the rifle was! He told me I could have the XXXX rifle. He had trouble with all of his guns.
We shot up 6000 rounds apiece in a 10 day trip. On the way home, he told me that he thought that my hits were 5 times greater than his and He would have good scopes with target knobs for the next years trip and muzzle breaks on his rifle. I informed him that I was going home for 3 weeks and coming back for another two week trip, he was welcome. That guy must have spend $10,000 dollars on guns, scopes, and barrels in the next 3 weeks!
On the next trip, he knocked the heck out of the dogs with those rifles that had target knob scopes. The dog town looked like it had rained dead dogs from Heaven, there were so many white belley's face up across the prairie. By the end of the trip, he had totally mastered the use of the target knobs and his miss ratio was minuscule compared to what he had been using before on the hold over method.
I carried many guys to SD and Wyoming over the years. Everyone of them use the "sight in at 200" method, and everyone of them were completely dissatisfied with their hit ratio because they could hear the loud "plops" of my bullets whacking dogs at just about any distance. One of two things happened from them watching my hit ratio shooting dogs in the wind and different angles, either they got scopes with target knobs or they would not go back with me.
Some guys just do not have the patience nor want to be bothered with screwing with knobs...it's just too much thinking and it takes out of their fun. Other guys don't have the money to convert over to scopes that are quality en ought to use target knobs. If you are only shooting 250 yards or so, you don't need target knobs at all. Some guys think that shooting at a dog 2-3 times before you hit him is OK, and that is a bunch of BS. Most guys think in terms of the wind being calm and 250 and under yard shooting.
To a guy that uses the hold over method, his worst nightmare is to pull up in SD and have a clear day with a 20 mph wind which happens often, like on the leading and trailing edge of a front moving in or leaving. How in the Hell do you use the hold over method when your zero has changed 12-14 inches horizontally and 4 inches vertically at 200 yards? In strong winds, all the dogs go down for 450 yards down wind, so the old theory of shooting with the wind is out the window! Strong winds make for just about an impossible day of shooting to a guy that uses hold over. To a guy that has target knobs, I angle with a direct cross wind, dial in 2=3 minutes of wind,4 clicks to a minute on a 1/4" scope and 8 Clicks to a minute on a 1/8" scope). The wind blows the sound away from the dogs on a direct cross wind, and I will kill all of them that stays up between 200-450 yards in a 20 mph wind shooting a 243 AI with 70g BT at 3850.
The rifles that do the best with a fixed zero are in calm winds and the super flat, fast shooting calibers.