In Mr Boyer's book he details a matrix shooting 5 charge weights at 5 seating depths = 25 total combinations to find the optium for both factors from one trial. While this is effective, it is not efficient and is only necessary if the behavior is extremely complex; there are numerous test designs which are both effective and efficient.
I use a combination known as a central composite design which evaluates five levels for each in 9 combinations. The following was shot by a friend using three shots each (n=27 total shots) , and he elected to repeat this on two different days. The Vert and Hor POI are measured, their spreads, and group size. Yes the spreads and group size responses based on 3 shots are statistically significant, but I will not bore you with those details. The point is that it is more efficient and effective to optimize both charge weight and seating depth at the same time vs individually.
I have used several different test designs in this vein to find the optimum during a single trial. When something unusual is observed, a little fine tuning followup provides clarrificaton.
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