A lot of good suggestions, 6XC, 243, too many good ones to mention, I'll offer one more, 6 Dasher with a 105 Berger, plenty of kill power at 300 for deer. And it is just fun on the range. I had a Dasher built for my Godson, dual purpose rifle, and worked with him most of the summer and into fall, watching him shoot it gives me pleasure. We took an antelope at 300 last weekend, bam, dead in it's tracks. Easy to load for too.