I would choose a twist for the caliber and bullet that I want to shoot, find a gunsmith that can throat accordingly.
Hondo64, the vast majority of 55-60g, 22 caliber bullets love to be seated at the lands, slight jam, or barely off the lands. This fact may have a huge impact of your success with lighter bullets.
Barrels that are throated for 75g bullets may indeed shoot well with light bullets while the throat is fresh, especially light bullets with more bearing surface vs VLD shape bullets, 55g Sierra semi point and sierra 63g semi point, 52g speer hp, and flat base 55g bullets.
Years ago, I was one of the first to shoot an 8 twist in the 6ppc with the brand new Berger 105's, and the tune window was very narrow. With the long leade required for the 105, I then tried to shoot the 68g bergers...not so good results.
At that time I was shooting thousands of p. dogs per year, and one of those guns was an HBAR that I shot the 55g Sierra BTHP in which shot groups around 3/4". The additional RPM's of the 7T in the HBAR made those normally tough 55's explode the p. dogs with dramatic acrobatics.
So, I built a 223 with a 9 Twist and a 22 PPC with a 9 Twist, both throated with a zero freebore reamer. I had custom 14 twists in both the 223 and the 22 PPC, both of which were easy to tune, the accuacy node and the window for the tune was spread over about 1.5g for each.
When I went with the 9T in the 223 and the 22 PPC shooting 50g Sierra Blitz, 55g Blitz, 50g tnt, 52g benchrest bullets, the tune window became quite narrow, and more temp sensitivity rose it's ugly head. 69g Sierra was the only heavy 22 caliber out then, and it is no p. dog bullet for my likes. Realize, I want to shoot three shot groups that will constantly print .100-.250, with wind flags and Leupold 36x as a load devopment scope.
So, I sold off the 9T 223 and 22 PPC. At this time, Benchmark, varget did not exist, and H322 was not an EXTREME powder at that time.
So, later on down the road, a shooting partner went with a 22/250 and shot the 75g bullets, his only comment was never again, 900 rounds of barrel life...short range coyotes/ chuck shooter. For a dedicated coyote hunting rifle, 900 rounds could be years of good use, but for a steel shooter, your barrel could be toast in no time. My friend wore his barrel out looking for loads and trying to find a bullet that blew up chucks.
I really like hot rods for coyote rounds, as a coyote can take a lot of killing.
22/250 AI with zero freebore, 12T, 60g Berger at 3700 with Winchester 760 gives good barrel life-detonates coyotes. Of all the coyotes I have killed over the years, I think that I have only shot at 5-6 that were between 450-500 yards.
For those Western states where the wind is howling all the time, those 75s in a 22/250 AI will give the best barrel life, acceptable shot strings in beween cleanings, with some super accuracy in the 3400-3500 fps area depending on barrel length. I would have the Rem 700 with a Wyatt's mag box installed.
IF and this is a big IF, you are willing to have a cleaning regiment that strict, then stomp on the gas and go to a 22-6 Rem AI and shoot the 80g A max at 3600 and not have pressure issues with cases like the 22-243 AI has with 80's trying to reach this speed, which is good for deer and hogs also.
The fast twist 22/250, 22/250 AI, 22-243 AI, and 22/6 Rem AI all have about the same barrel life, 900-1200 rounds depending on your use and care. I talked to one guy where he got more usable barrel life with the 80g A max(1500 rounds), perhaps due to bullet length, all he does is shoot coyotes with his 6 Rem AI with a mid pressure load of Retumbo with 3600 velocity(capable of 3700+).