To me this is exceedingly simple. Rule #1 is to make sure the throat is dialed in concentric to the lathe spindle. Preferably with a high quality direct reading indicator. After that, there are a couple of options.
1. Drill and prebore. This makes the breech area, both the tenon and chamber, concentric to the dialed in in throat so the chamber is straight.
2. Dial in the breech as well as the throat and use a finish reamer without preboring. If you make that 3" of barrel straight, then the tenon and chamber will be straight.
I use method 2 right now. I personally find it is faster and there are less things to mess up. And yes, fired brass from these chambers comes out at or under reamer spec.
I have chambered a several dozen hunting rifle barrels over the last few months, many of which are those stupid, button rifled, carbon wrapped POS barrels with more than .050" of muzzle runout when the throat and breech are dialed in, AND have uneven rifling. They all shoot sub 1/2 MOA at 650 yds when we do the load development.
My personal LRBR barrels shoot very competitively as well. While I don't pretend to do as good of a job as
@Alex Wheeler or anyone else, it's isn't my chamber jobs that open my groups. My competition group size is determined by how much effort I put into tuning and how well I adjust to the conditions.
BTW, because he was mentioned, Bruce Thom absolutely knows what he is doing. If there is disagreement with what someone thinks they heard him say, well, go to the source.
I watched him set up a big heavy lathe to cut chambers with a rigid reamer setup. That method in that kind of lathe absolutely requires drill and prebore. The chamber jobs from that lathe come out perfect with no tool marks, even when a new lathe operator cuts the chamber.