I sent many, many prairie dogs to the great pasture in the sky courtesy of a .22LR. Started out with an old single-shot Remington 510T w/ iron sights - my 'magazine' was the other five rounds I held in my lips... pre-lubed w/ spit, I guess

Later moved on to a little Browning BL-22 w/ a Bushnell 4x on top. Eventually, I stepped up to a Remington 788 in .223 Rem w/ a Tasco 6-24x range-finding scope, but kept the .22LR handy as teenage funds were limited, and even back then buying .223 Rem could break the ole' piggy bank in a hurry.
It's amazing what you can accomplish with a .22LR when you don't know it's 'not enough gun'.
Yes, I spent part of the time on my belly doing the low-crawl across the prairie to sneak up close enough - 50yds and a good head/upper-torso shot and it was usually lites out for the little buggers. There were some exceptions... had one that I had to do two to the chest, one to the head because he kept getting back up,armor plated prairie dog? post mortem revealed good dead center shots that normally would have dropped one in their tracks and kept 'em there). Then there was that time crawling thru the pasture and coming nose to nose w/ Brer Snake - as in 'rattle' snake.
As mentioned, you don't need a fancy rig. One of the old boys I learned from had about as redneck of a setup as I've seen... and old Ruger #1 w/ a straight stock, barrel band front sight, etc. in .223 with,by our best guess) 20k+ rounds through the barrel,at least) - he'd fill up an ice cream pail full of loaded rounds, put 'em in another once they got fired. An old Bushnell 3-9x scope on top, and a rolled up sleeping bag on the hood or the cab of his little Mazda pickup was his 'rest'. And that guy just killed the hell out of the 'dogs every year.
Still kept a .22 LR, even if it's just a pistol like a Ruger MkII or Browning Buckmark, handy for the occasional p-dog determined to commit suicide by popping up about 50 feet off the end of the bench. They work dang good on snakes at about 20 inches, too.
