Yes, some reticles absolutely can give your eyes fits.
Long ago and far away, I did pretty well in my first round on the big stage (2nd in FCNC) with (at the time) a nice NF BR scope with the 2DD reticle. For my next scope, I figured 'aim small, miss small', right? So I ordered one with a CH3 reticle, which IIRC was super fine lines, a small gap, and little pin-prick of a dot. Worked super well when doing load workup and practice - on white paper with orange target-spots. First match I took it to was down in Oregon, outside Portland, on a dark/dreary weekend. I'd completely lose the damn reticle no matter how I adjust the parallax, rear diopter, nothing. I'd get on target, and after about 5 seconds, the reticle would just fade away leaving me a beautiful view of the target... and no way to aim at it.
I found that I could work around it - sort of - by focusing on something close. Looking down at my thumb on the stock, on the back of the bolt, the ground beneath the gun, and let my eyes relax - then back up to the scope, aim hold fire, all in about five seconds or less. Not great, but at least I could finish the match. Sent that scope back to get another 2DD reticle when I got home.
Years later, when the US FTR team got the NF Comp scopes, the first one I got (not by choice) was some bastard love child of the CH-3 and what later became the FCR-1. Imagine the FCR-1 with the gap and center dot of the CH-3. F$ck me...
The FCR-1 I actually did okay with, once it showed up. I didn't use the brackets so much for hold offs (I usually use the scoring rings, unless I'm holding off paper!) as much as for times when the mirage was really bad and I had to bracket the frame. Anywho, I find my eyes pretty much need either a bigger center dot, or solid lines going all the way in to the center to keep from 'losing' the reticle. The 2DD? Still works great. The DDR2? Can't use it, too fine/small. The Vortex ECR-1? Can't use it either. The SCR-1? Not my first choice, being a plain reticle with no dot, but with the lines at least I can see them all the way to the center.
I'm thinking my next scope will probably be a March HM... with the 1/8" moa center dot. Everyone else keeps going smaller and smaller, but I just can't see/use them.
As an aside, I do have a pretty heavy prescription (5.50-5.75 diopters), some astigmatism, and this is probably the key, some retinal issues due to diabetes. Pretty sure that's also why I can't see the mirage nearly as well as I used to, no matter what glass I get behind.