SRP ignition gives
very different results from LRP in this size of case, powder charge type and weight. This is a normal expectation among 308 Win Lapua Palma SRP brass users for instance and charges are adjusted upwards almost as a matter of course.
Far from 50 fps being an abnormal reduction, it's pretty common in this size of cartridge, and I've seen larger MV reductions in some comparisons. SRP charges usually have to be adjusted up by 0.5 to 1.5gn on an LRP to SRP switch in Creedmoor / 308 Win size cases depending on charge weights and the powder burn-rate and/or how easily it ignites.
The cause is that SR primers are far less aggressive than LR equivalents and the volumes / weights of super-heated gas and solid ejecta that they force into the powder column is much reduced. If ambient temperatures are low and the case-body brass and powder kernels cold, they have much less energy available to heat those items up and reach the temperatures that give consistent ignition. That's why Lapua advises against this type of brass in cold weather hunting. If your testing was done in anywhere close to freezing point never mind below, this may also have affected your results. Lapua and Peterson SRP cases also come with smaller diameter flash-holes than LRP equivalents - 1.5mm vs 2mm - and this affects ignition too. (It improves consistency reducing MV spreads where it works well, but can make a poorer job of igniting the powder column in non-optimal situations.) Finally, SRP ignition doesn't work at all well with some powders. I couldn't get it to work in 308 with Hodgdon CFE-223 for instance - two complete misfires and almost every other round a mild hangfire.
As an example of MV reduction, have a look at:
http://www.targetshooter.co.uk/?p=2621
at a table at the very end of the piece on 308 Win / 167gn Scenar / Viht N150 LRP and SRP MVs fired side by side in a single session, both in Lapua brass with very close fireformed water capacities.
The final point to note is that not only does SRP brass require heavier charges, but it has very strong case-heads due to the primer pocket being smaller and removing less metal from a key pressure-bearing area of the case. As a result a full-pressure charge worked up in an SRP case should never be transferred as is to LRP cases even of the same make. It is essential to drop charges and work up again.