That's a good question. You will find a lot of different opinions regarding Optimized Barrel Time here. Some swear by it, some think it is not valid, or at least not well-explained and not consistent with different rifles/loads. In my hands, the OBT Nodes as listed for different barrel lengths in Chris Long's Table have proven to shoot quite well. In fact, when I first started reloading, I didn't have QuickLoad or any knowledge about barrel occupancy times at all. Nonetheless, I later went back and documented using QL the first three loads I had previously worked up for different rifles/calibers. Every single one of them was spot on the barrel time predicted for Node 4 for a 30" barrel. In my opinion, there is no way that is mere coincidence, as there were three different loads involved, with three different bullet weights, two different powders, and two different rifles. So I think there is something to the OBT Nodes, but the provided explanation involving longitudinal shockwaves through the barrel steel is a little hard to digest. My gut feeling is that OBT Nodes may have more to due with traditional barrel timing with respect to barrel harmonics, but that is merely a feeling and I have no way to prove that conclusively.
IF (and that can sometimes be a big "if") you can hit a particular OBT Node with a given powder, bullet weight, and barrel length, there is no good reason not to evaluate load performance using QuickLoad and barrel times. If a load doesn't look good within a reasonable range of barrel times surrounding the purported OBT Node, then you have to keep looking. However, when it works, it seems to be pretty obvious, at least in my hands. One of the major values of using a program such as QL is to be able to use the barrel time output for the purpose of targeting OBT Nodes. In that event, the use of the software can certainly facilitate and expedite the reloading process. If you cannot hit a given OBT Node due to barrel length, bullet, or powder selection, the program is somewhat less useful, although having solid pressure/temperature predictions is never a complete waste of time, IMO. The good news is that reloading programs are not essential for developing solid loads. They can sometimes help, but you can reach the same endpoint regardless of whether you use a reloading program or not. So I try to take advantage of their use to facilitate load development when/if it appears that a given load will fall very close to a predicted OBT Node, but am not dependent on the software when the load clearly isn't going to be close to an OBT Node. Another benefit to having QuickLoad is that you make very good predictions as to what barrel length you need with a given powder and/or bullet weight to actually target a specific OBT Node. That is not necessarily always helpful with an existing setup, but can be very useful to help you choose barrel length, freebore length, etc., when deciding on specs for a new barrel.