The first time I used Hornady One Shot Lube I used it on 50bmg and my Hornady Lock and Load Press. Locked up tighter than anything..... broke the casting on the press trying to remove the brass. Called Hornady and the first thing the rep said was "You shouldn't use it on that". They sent me a new casting for free and I still use it but not on 50 bmg. FWIW