Larger ES/SD can be a factor, but, mainly in long range work. As stated above, the differences at 100yd are small. The BR competitors will see the difference, but, I won't. At 600yd it does show up and at 1000yd it can be significant, usually showing up as vertical stringing.
Being on or off a node is much more important. I notice that nodes near max pressure (or a bit over

) are fairly narrow, so ES/SD will have more of an effect than if you are working at a lower/wider node.
When you get the best of both, node and low ES/SD, you are in business. Some cartridges are 'easier' than others to get the low ES/SD numbers. The 6BR is one of those. Some are not, the .223 comes to mind.