Thanks to Alex Wheeler for initiating this discussion. The fire control system (FCS) is a complex and imperfect system. Every mechanical system has a Mean Time Between Failure (MTBF). In many industrial applications, these are calculated and published. We can't get that kind of information on firearm fire control systems, due to the system being "open." In other words, anybody from the manufacturer to the end user can "get into" the FCS and make changes. We alter every item from the trigger bow to the firing pin tip. Springs, triggers themselves, and safeties are taken apart, replaced, and put back together; and this introduces potential failure modes. Even after a thorough check, there may be changes in the system from repeated use, vibration, recoil, time, moisture, temperature, etc. They can't ever be trusted. Safety being the goal, we must assume the FCS is going to malfunction every time it's needed.
I suspect that in Africa, when walking in the bush, the concept of safety requires having a round ready to use, in order to protect yourselves from sudden danger. In that case, the decision has to balance all the factors involved, and that decision rests with your Professional Hunter. You do what he tells you.
We all have our personal opinions, but we should share the goal of safety. Alex may save somebody's life by posting this notice, and we may all share the credit by posting additional information, and encouraging each other to learn more about Fire Control Systems, as well as other "process issues" that can have an effect on safety.