VaniB said:...I saw police shooting videos of how full sized 45's DON'T ALWAYS STOP CRAZED DRUGGIES.
There's something to be said for 185 grain HP's in this situation, if they're proven to penetrate a layer or two of denim & still open up. Mandates frequently specify ball / FMJ 230 grain which don't produce much of a wound cavity / hydraulic shock at 900 fps.
I agree on 40's though, or 357SIG. Choose your factory load for low/no flash & proven fabric penetration. Practice with hand loads loaded to match velocity if you want to but if push comes to shoot you want factory ammo doing the talking for you. Hand loads will just give the DA more fuel to feed the fire under your feet.
If you haven't already, you might find it interesting reading what's collected here:
http://www.ar15.com/ammo/project/Self_Defense_Ammo_FAQ/
- for our viewing pleasure. It's a little old though so Hornady's Critical Defense product isn't mentioned.