I have a 22-6mm that was purpose built around 75+ grain bullets (1:8 twist). If I am very careful with it and space my shots way out, it should last 1,000 rounds or so.To the gentlemen with your large capacity 22's (22-6mmAI, 22-243, etc.), are these barrel burners? I have a 12T 223AI which I have only been able to achieve +/-3800 fps before running into pressure using 50-52gr bullets, but I will explore the 40's this season.