I have seen neck shoots fail, they only work if you hit the back bone.  I had a bull moose run 100yds, very fast after a heart shot.  The 225gr .338 was recovered on the off side leg/ shoulder joint 191grs.  Use heavy bullets for heavy game.  I would use the .375 unless you are shy of it because of recoil, then down load so it does not bite so bad.  Muzzle breaks really work too.  I put a break on my .338 mag because of the range time, it was beating me up.  I've shot a .338-06 for years but the 338 mag kicks a lot more, 10gr powder and 150 ft/sec in a 1/2 lb lighter gun was too much so a break did the trick.
				
			
	








