If speed drops below 2000 it could cause problems but that actually applies to any hunting bullet. Test have shown a 30-06 penetration at 500yds to be equal to or better than at 50 yards, why because the bullet doesn't expand !I've had problems with the Barnes x ttsx 338/210gr opening at ranges longer than 400 yards and that's leaving the muzzle at 3170 have you had this experience with any Barnes bullets after 400 yards.. I shot them into wet phone books at 400 and 500 yards after they wouldn't open call the guy at Barnes bullets he said they wasn't getting enough hydraulics to open he suggested I put a gallon of water in front of the phone books and I did that and still have the same exact results.