Been shooting wheel guns since the 60's. My all time favorite is the Model 17, Smith and Wesson, 22 long rifle in 6" barrel. I've shot bullseye competition with it (qualified distinguished expert), hunter pistol silouette (qualified AAA), and used for small game hunting. I have over 100,000 rounds through mine and it still shoots better than I can. Best pistol I've ever own and I've own a bunch.
As far as centerfire, I've shot and loaded the 44 magnum, 357 magnum, and 38 special. My favorite target pistol is the Model 14, S&W, 38 special in 6" barrel. My favorite carry gun is the Model 19, S&W, 4" barrel loaded with 38+P's in 125 grain XTP's and my favorite heavy duty pistol is the Model 586, S&W, in 6" barrel loaded with 140 grain XTP with 2400 powder. For big game hunting the S&W Model 29, 44 magnum in 240 grain soft points with 2400 powder is the excellent.
If you're looking for the ultimate target load in 38 special, the 148 grain swaged hollow base wadcutter behind either bullseye or 231 in a 38 special case is the way to go. Loaded at target velocities, i.e. 750 to 800 ft/sec., it is capbale of X ring accuracy at 50 yards and it will not lead your barrel. I shot the S&W Model 14, 6" barrel 38 special for many years in competition and it is capable of such accuracy. I did use special custom grips with a recoil horn to control the pistol in time and rapid fire.
I've not noticed a significant drop off in accuracy shooting 38 special reloads in a 357 chamber but would not recommend this for bullseye shooting but who shoot a revolver in bullseye anymore; probably no one.
For high terminal performance, the Hornady XTP's are very good especially when loaded to 357 magnum velocity with 2400 powder.
Another excellent bullet for general shooting and target practice is the Oregon Trail Laser Cast bullets. Very accurate and will not significantly lead the barrel when loaded to moderate velocities.
Hope this is helpful.