Well there were (allegedly) a few with air to air refueling capability. This was never really pursued very far as the pilots endurance was fading quickly even after a non-refueled flight.
Additionally U-2's required a different jet fuel than other jet aircraft use due to their high altitude. Aside from security, the bases they flew from had to stock that fuel.
I can't imagine how much was going on in the pilots head all the time.
From personal experience I can tell you EXACTLY what goes in inside a USAF pilot's mind. So can @drano38 .........
