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Not sure your discipline, But 4350 is a proven winner on the 180 hybrids in F class comp. That combo has won some major national shoots in the past. RL-16 is very close to the same burn. I've ran 16 on the 180 hybrids with great results, But that bullet seemed to like it more down in the .284 velocity's of 2830-2850. It never agged as well for me on the upper node. But a lotta wood been won up in the 3000 area, but your gonna pay the fiddler on throat erosion for sure. 16 is very temp stable and it always pulls less copper than other powders with heat on these long strings from what i've seen as well. I would definitely take a look at the RL-23 on your combo. Its burn is right between 4350-4831. These new berger 190's coming out with a dab of 23 might need a look at to.