I don't have fat fingers but that could make it tougher. Mostly the idea of needing precise load weight. Not that I'm sloppy on my loading now. But I usually use the Dillion 650 for volume reloading. And the 221 Fireball works for me just fine.reloaded and shot hundreds of the 4.6x30 necked to 17 cal. ( 17vha) and they are just a easy to reload as the 17 hornet.
Don't know why a 5.7x28 would be any harder to do so, with the proper dies.