Its unusual that you opt for a very large magnum handgun with a normal rifle scope?... I would think an EER scope would make more sense otherwise what is the point of using a handgun that you cannot stretch out to arms length? I wouldnt want my face that close to a 33 Nosler without shoulder support on the weapon when it goes off.
Ask Randy how much the pistol weighs. Then you will understand.
I have a 338-375 Ruger which is pretty much identical in size and case capacity to the 33 Nosler.
Powders in the H4350 and RL-16 seem to work best for speed and accuracy using +/- 250gr bullets. I prefer RL-16 over H4350 due to better case fill. For 300 grain, you might want to use a little bit slower powder.
I will tell you right now that the muzzle report and recoil will be significantly more than any 7mm rounds you are accustomed to. Muzzle brake or not, she will bark! Keep your mouth closed when shooting or you might chip a tooth