I've used N165 in the straight 284 for years with the 180gn SMK marginally into the lands, and in the rifle's early years, the 180 Scenar-L jumped. Lapua brass (6.5-284 necked up) and the mild PMC (Russian) LR primer. COAL: 3.1-inch; actual fireformed case water capacity 66.7gn. Bartlein 30-inch 4-groove gain twist ending up as one in eight inches.
Early on with the barrel new, I worked up to 57.0gn which gave around 2,830 fps. This later speeded up to over 2,850, maybe a bit more, and a short-range check showed groups had opened up. The charge was dropped and fine-tuned in the 54-55.5 gn range ending up at 55.0 which is what I still use with 2,300 rounds down the barrel and still shooting well. At the time of charge adjustment, that gave 2,825 fps. Throat wear has been modest, the COAL increased to put the ogive back into light engagement sometime between the 1,200 and 1,500 round count level.
I've never had the slightest pressure issue with this combination (irrespective of what QuickLOAD calculates); primer pockets on the original cases are still tight with one batch having been fired 13 times. I don't even FL size, using a Forster Bushing-Bump die (modified 6.5-284 as Forster doesn't make this model for the 284 proper), and bolt opening and extraction are very, very easy (Barnard 'P'). This is 980 ft ASL on an exposed range in northern England, so no very hot days here (in fact, not very many mildly warm days!).
However, to reinforce the caveat that every rifle / barrel / chamber is different, a friend who shot a similar rig (Barnard / Bartlein) in BR Heavy Gun also with Lapua brass (IIRC with the CCI-BR2 and Berger 180gn Hybrids) had to drop charges pronto after blowing a couple of primers with 57gn.