Reeper, regarding the brass life with the 300 Varminter. The 300 Varminter can push the 110grn V-Max at a velocity of 4100fps, however, you will only get about 3 firings per case. If you shoot the 110grn V-Max between 3900 to 4000fps, brass life improves a great deal.
"ONCE AGAIN, A FACTORY 300 WSM WILL NOT GET THE VELOCITIES MENTIONED ABOVE!!"
You can push the 125grn BT at a velocity of 3950 to 4000fps but you only get about 3 firings if you push it that fast. However, if you push the 125grn BT at around 3800 to 3850fps, brass life improves a great deal.
I plan to run the 110grn V-Max at around 3950fps and the 125grn BT at around 3850fps. This will allow me to get more life out of the cases.
Regarding action, barrel, scope, ect. I am using a Nesika Model K 1.470 diameter action, Bartlein 30" 1-15 twist 1.250 straight cylinder barrel, Jewel Trigger, Richard's #8 Long Range Varmint F-Class stock, Vias Muzzle brake, Nesika 20MOA Rail, Nightforce 30mm Rings, and I topped it off with a Nightforce 8x32x56mm Scope with MLR retical. The rifle will weigh around 25 pounds with scope.
I had it built for low volume varmint and coyote hunting out to 600 and 800 yards depending on what bullet I use. The other cartridges mentioned, such as the 22-250AI, 220Swift, 220 Rocket, and 6MM AI are also excellent coyote cartridges too. One of my varmint hunting buddies uses a 220 Swift with a 55grn V-Max for varminting and coyote hunting out to 500 yards. He has done very well with the 220 Swift. Anyhow, I hope I answered your questions.
If you have questions regarding the 300 Varminter, go to Richard's Custom Rifles web page. Also, if your wanting to build a varmint rifle, I would highly recommend Richard Franklin.
VH